Tg(Prnp-HTRA2*G399S)1Olri
Transgene Detail

Summary

• Symbol: Tg(Prnp-HTRA2*G399S)1Olri
• Name: transgene insertion 1, Olaf Riess
• MGI ID: MGI:5790703
• Synonyms: Tg(Prnp-OMI*G399S)1OlRi
• Transgene: Tg(Prnp-HTRA2*G399S)1Olri Location: unknown
• Alliance: Tg(Prnp-HTRA2*G399S)1Olri page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-HTRA2*G399S)1Olri expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTRA2 (27429)

  Htra2

  (MGI:1928676)

• Mutation details: The human cDNA containing the G399S mutation with a FLAG tag at the C-terminal is under the control of the mouse prion promoter. This line has a relative copy number of ~4. Mice express around five times the amount of endogenous RNA levels. (J:229160)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:229160 Casadei N, et al., Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. Hum Mol Genet. 2016 Feb 1;25(3):459-71
• All: 1 reference(s)