Slc38a3^m1Ingm
Chemically induced Allele Detail

Summary

• Symbol: Slc38a3^m1Ingm
• Name: solute carrier family 38, member 3; mutation 1, Ingenium Pharmaceuticals AG
• MGI ID: MGI:5790979
• Synonyms: Snat3-Q263X
• Gene: Slc38a3 Location: Chr9:107528353-107546167 bp, - strand Genetic Position: Chr9, 58.69 cM, cytoband F1
• Alliance: Slc38a3^m1Ingm page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to T mutation that results in the amino acid substitution of a termination codon for glutamine at position 263 (Q263X). The mutation causes a premature stop codon deleting the second half of the protein. Western blot analysis confirmed the absence of protein expression in the brain, liver and kidney. (J:234835)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc38a3 Mutation: 31 strains or lines available

References

• Original: J:234835 Chan K, et al., Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney. Pflugers Arch. 2016 Feb;468(2):213-27
• All: 1 reference(s)