Cd82^tm1.1Xaz
Targeted Allele Detail

Summary

• Symbol: Cd82^tm1.1Xaz
• Name: CD82 antigen; targeted mutation 1.1, Xin A Zhang
• MGI ID: MGI:5790985
• Gene: Cd82 Location: Chr2:93249447-93293295 bp, - strand Genetic Position: Chr2, 51.62 cM
• Alliance: Cd82^tm1.1Xaz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234155
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette with a 5 loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 6. Cre-mediated recombination removed the selection cassette and exons 5 and 6. Western blot analysis confirmed the absence of protein expression in the spleen, T cells, B cells and dendritic cells. (J:234155)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd82 Mutation: 19 strains or lines available

References

• Original: J:234155 Wei Q, et al., CD82 restrains pathological angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cells. Circulation. 2014 Oct 21;130(17):1493-504
• All: 4 reference(s)