Myo15a^mpc190H
Chemically induced Allele Detail

Summary

• Symbol: Myo15a^mpc190H
• Name: myosin XVA; muta-ped-c3pde 190, Harwell
• MGI ID: MGI:5792022
• Gene: Myo15a Location: Chr11:60360165-60419195 bp, + strand Genetic Position: Chr11, 37.81 cM
• Alliance: Myo15a^mpc190H page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to G point mutation that results in the amino acid substitution of glycine for aspartic acid at position 1647 (D1647G). (J:234901)
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Myo15a^mpc190H/Myo15a^mpc190H	involves: BALB/c * C3H/HeH * C57BL/6J

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
hearing/vestibular/ear	√
deafness	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo15a Mutation: 136 strains or lines available

References

• Original: J:234901 Potter PK, et al., Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Nat Commun. 2016;7:12444
• All: 1 reference(s)