Pisnl2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Pisnl2^C57BL/6J
• Name: paraquat-induced substantia nigra pars compacta neuron loss 2; C57BL/6J
• MGI ID: MGI:5792052
• QTL: Pisnl2 Location: unknown Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:184231

Linkage analysis was perofrmed on a mapping population of 61 backcross (C57BL/6J x SWR/J) N2 mice to identify QTL related to paraquat-induced neuron loss in the substantia nigra pars compacta (SNpc) of the brain. C57BL/6J mice rapidly lose approximately 50% of their SNpc dopaminergic (DA) neurons, whereas inbred Swiss-Webster (SWR/J) mice do not show any significant loss. F1 crosses were generated by mating male C57BL/6J mice with female SWR/J mice and female C57BL/6J mice with male SWR/J stock. F1 hybrids were backcrossed to SWR/J to generate a set of 61 backcross (N2) progeny that were used to map QTLs. Mice were genotyped at 60 informative MIT markers (NCBI build 37 (mm9) mouse genome assembly). Two QTL reaching genome-wide significance were identified:

QTL Pisnl1 (paraquat-induced substantia nigra pars compacta neuron loss 1) maps to Chromosome 5 with a peak near D5Mit338 at 109 Mb (LOD score not given). The C57BL/6J allele is associated with an increased loss of SNpc DA neurons at the Pisnl1 locus.

QTL Pisnl2 (paraquat-induced substantia nigra pars compacta neuron loss 2) maps to Chromosome 14 with a peak near D14Mit206 at 21.5 Mb (LOD score not given). The C57BL/6J allele is associated with an increased loss of SNpc DA neurons at the Pisnl2 locus.

References

• Original: J:184231 Jiao Y, et al., Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta. PLoS One. 2012;7(1):e29447
• All: 1 reference(s)