Slc26a5^mpc234H
Chemically induced Allele Detail

Summary

• Symbol: Slc26a5^mpc234H
• Name: solute carrier family 26, member 5; muta-ped-c3pde 234, Harwell
• MGI ID: MGI:5792083
• Gene: Slc26a5 Location: Chr5:22015653-22070602 bp, - strand Genetic Position: Chr5, 9.97 cM, cytoband A3
• Alliance: Slc26a5^mpc234H page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to T point mutation that results in the amino acid substitution of valine for glycine at position 379 (G379V). (J:234901)
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	Slc26a5^mpc234H/Slc26a5^mpc234H	involves: BALB/c * C3H/HeH * C57BL/6J

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
hearing/vestibular/ear	√
deafness	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc26a5 Mutation: 58 strains or lines available

References

• Original: J:234901 Potter PK, et al., Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Nat Commun. 2016;7:12444
• All: 1 reference(s)