Hdac6^tm1Anfi
Targeted Allele Detail

Summary

• Symbol: Hdac6^tm1Anfi
• Name: histone deacetylase 6; targeted mutation 1, Andre Fischer
• MGI ID: MGI:5792141
• Gene: Hdac6 Location: ChrX:7796359-7814128 bp, - strand Genetic Position: ChrX, 3.58 cM
• Alliance: Hdac6^tm1Anfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234763
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 10-13. Semi-quantitative PCR and immunoblot analysis confirmed absence of mRNA and protein levels in the hippocampus and cortex of homozygotes. (J:234763)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Hdac6^tm1Anfi/Hdac6^tm1Anfi	Not Specified
cx2	Hdac6^tm1Anfi/Hdac6^tm1Anfi Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?	involves: C57BL/6

Phenotypes:

Affected Systems	hm1	cx2
show or hide all annotated terms Sex:
behavior/neurological	√	N
behavior/neurological phenotype	N	N
abnormal spatial reference memory	√
cellular	N
cellular phenotype	N
homeostasis/metabolism		√
amyloid beta deposits		√
nervous system	N	√
nervous system phenotype	N
amyloid beta deposits		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac6 Mutation: 17 strains or lines available

References

• Original: J:234763 Govindarajan N, et al., Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. EMBO Mol Med. 2013 Jan;5(1):52-63
• All: 1 reference(s)