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Hdac6tm1Anfi
Targeted Allele Detail
Summary
Symbol: Hdac6tm1Anfi
Name: histone deacetylase 6; targeted mutation 1, Andre Fischer
MGI ID: MGI:5792141
Gene: Hdac6  Location: ChrX:7796359-7814128 bp, - strand  Genetic Position: ChrX, 3.58 cM
Alliance: Hdac6tm1Anfi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234763
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exons 10-13. Semi-quantitative PCR and immunoblot analysis confirmed absence of mRNA and protein levels in the hippocampus and cortex of homozygotes. (J:234763)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Not Specified
 
involves: C57BL/6
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
   
behavior/neurological
N
behavior/neurological phenotype
N N
abnormal spatial reference memory
cellular
N
cellular phenotype
N
homeostasis/metabolism
amyloid beta deposits
nervous system
N
nervous system phenotype
N
amyloid beta deposits
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac6 Mutation:  17 strains or lines available
References
Original:  J:234763 Govindarajan N, et al., Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. EMBO Mol Med. 2013 Jan;5(1):52-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory

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