Hjv^tm1Kpan
Targeted Allele Detail

Summary

• Symbol: Hjv^tm1Kpan
• Name: hemojuvelin BMP co-receptor; targeted mutation 1, Kostas Pantopoulos
• MGI ID: MGI:5792151
• Synonyms: Hfe2^f
• Gene: Hjv Location: Chr3:96432488-96436526 bp, + strand Genetic Position: Chr3, 41.91 cM
• Alliance: Hjv^tm1Kpan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231428
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exons 2 through 4 were floxed. A neomycin resistance cassette is present. (J:231428)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hjv Mutation: 19 strains or lines available

References

• Original: J:231428 Gkouvatsos K, et al., Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin. Hepatology. 2011 Nov;54(5):1800-7
• All: 1 reference(s)