Ptchd1^tm2.1Gfng
Targeted Allele Detail

Summary

• Symbol: Ptchd1^tm2.1Gfng
• Name: patched domain containing 1; targeted mutation 2.1, Guoping Feng
• MGI ID: MGI:5792576
• Synonyms: Ptchd1 fl
• Gene: Ptchd1 Location: ChrX:154356451-154406810 bp, - strand Genetic Position: ChrX, 72.38 cM
• Alliance: Ptchd1^tm2.1Gfng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232709
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector containing a FRT-site flanked NEO selection cassette was used to insert loxP sites flanking exon 2. This selection cassette was inserted downstream of exon 2 of the targeted gene, and another loxP site was inserted upstream of exon 2. Flp-mediated recombination removed the selection cassette. (J:232709)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Ptchd1^tm2.1Gfng/Y Sst^tm2.1(cre)Zjh/Sst^+	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms Sex:
behavior/neurological	√
behavior/neurological phenotype	N
abnormal cognition	√
hyperactivity	√
fragmentation of sleep/wake states	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptchd1 Mutation: 11 strains or lines available

References

• Original: J:232709 Wells MF, et al., Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice. Nature. 2016 Apr 7;532(7597):58-63
• All: 2 reference(s)