Esyt3^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Esyt3^{tm1d(EUCOMM)Wtsi}
• Name: extended synaptotagmin-like protein 3; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:5792823
• Synonyms: 3KO, Esty3 delta
• Gene: Esyt3 Location: Chr9:99192016-99240610 bp, - strand Genetic Position: Chr9, 51.54 cM
• Alliance: Esyt3^{tm1d(EUCOMM)Wtsi} page
• IMPC: Esyt3 gene page

Mutation origin

• Mutant Cell Line: EPD0458_5_A10
• Germline Transmission: Earliest citation of germline transmission: J:232605
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre- and Flp-mediated excision of the parental Esyt3^{tm1a(EUCOMM)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette, the IRES-BetaGal reporter expression cassette and critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:232605)

Expression

In Mice Carrying this Mutation:

57 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esyt3 Mutation: 43 strains or lines available

References

• Original: J:232605 Herdman C, et al., Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected. Cell Cycle. 2014;13(16):2616-25
• All: 4 reference(s)