Smad4^tm1.1Gsu
Targeted Allele Detail

Summary

• Symbol: Smad4^tm1.1Gsu
• Name: SMAD family member 4; targeted mutation 1.1, Gloria H Su
• MGI ID: MGI:5792845
• Synonyms: SMAD4^flox
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm1.1Gsu page

Pancreatic fibrosis and acinar-to-ductal metaplasia in Tg(MtTGFA)Lmb/0 (MT-TGFalpha) and Smad4^tm1.1Gsu/Smad4^tm1.1Gsu Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Tg(MtTGFA)Lmb/0 (STP) mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Exon 9 was flanked by loxP sites and a FRT-flanked PGK-NEO cassette was inserted between the first loxP site and exon 9. Flp-mediated recombination removed the PGK-NEO cassette leaving exon 9 floxed. (J:229184)

Generation of the Smad4^tm1.1Gsu allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 48 strains or lines available

References

• Original: J:229184 Garcia-Carracedo D, et al., Smad4 loss synergizes with TGFalpha overexpression in promoting pancreatic metaplasia, PanIN development, and fibrosis. PLoS One. 2015;10(3):e0120851
• All: 1 reference(s)