Ddah1^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Ddah1^tm1.1Geno
• Name: dimethylarginine dimethylaminohydrolase 1; targeted mutation 1.1, Genoway
• MGI ID: MGI:5792874
• Synonyms: DDAH1^-
• Gene: Ddah1 Location: Chr3:145464447-145600032 bp, + strand Genetic Position: Chr3, 70.63 cM, cytoband H3
• Alliance: Ddah1^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234529
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed exon 1 was removed. Western blot analysis confirmed the absence of protein expression in the kidney and liver. (J:234529)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddah1 Mutation: 18 strains or lines available

References

• Original: J:234529 Dowsett L, et al., Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis. Circulation. 2015 Jun 23;131(25):2217-25
• All: 1 reference(s)