Aldh1b1^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Aldh1b1^{tm1.1(KOMP)Vlcg}
• Name: aldehyde dehydrogenase 1 family, member B1; targeted mutation 1.1, Velocigene
• MGI ID: MGI:5792875
• Synonyms: Aldh1b1^tm1LacZ
• Gene: Aldh1b1 Location: Chr4:45799022-45804604 bp, + strand Genetic Position: Chr4, 24.35 cM, cytoband B2
• Alliance: Aldh1b1^{tm1.1(KOMP)Vlcg} page
• IMPC: Aldh1b1 gene page

Mutation origin

• Mutant Cell Line: 11807A-E11
• Germline Transmission: Earliest citation of germline transmission: J:232360
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 1589bp between positions 45815339-45816927 of Chromosome 4 (Genome Build37). A loxP-flanked PKG-neo selection cassette was removed via Cre-mediated recombination. (J:232360)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aldh1b1 Mutation: 35 strains or lines available

References

• Original: J:232360 Anastasiou V, et al., Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia. 2016 Jan;59(1):139-50
• All: 3 reference(s)