Rfx2^tm1.2Wrth
Targeted Allele Detail

Summary

• Symbol: Rfx2^tm1.2Wrth
• Name: regulatory factor X, 2 (influences HLA class II expression); targeted mutation 1.2, Walter Reith
• MGI ID: MGI:5792885
• Synonyms: Rfx2^-neo⁺
• Gene: Rfx2 Location: Chr17:57082897-57138013 bp, - strand Genetic Position: Chr17, 29.5 cM, cytoband D
• Alliance: Rfx2^tm1.2Wrth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228765
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette was inserted downstream of a floxed exon 7. Cre-mediated recombination removed exon 7. The selection cassette remains intact. (J:228765)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rfx2 Mutation: 79 strains or lines available

References

• Original: J:228765 Kistler WS, et al., RFX2 Is a Major Transcriptional Regulator of Spermiogenesis. PLoS Genet. 2015 Jul;11(7):e1005368
• All: 1 reference(s)