Ddx60tm1b(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Ddx60tm1b(EUCOMM)Wtsi |
Name: |
DExD/H box helicase 60; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5792890 |
Gene: |
Ddx60 Location: Chr8:62381121-62490735 bp, + strand Genetic Position: Chr8, 31.51 cM
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Alliance: |
Ddx60tm1b(EUCOMM)Wtsi page
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IMPC: |
Ddx60 gene page |
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Mutant Cell Line: |
EPD0327_7_A05 |
Germline Transmission: |
Earliest citation of germline transmission:
J:228452
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 62407097 of Chromosome 8 upstream of the exon 9 (Build GRCm39; exon 10 in J:228452). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 9 (or exon 10 J:228452) at position 62407909. Cre expression resulted in the deletion of the targeted exons and neomycin selection cassette, creating a reporter knockout mouse.
(J:228452)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ddx60 Mutation: |
96 strains or lines available
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Original: |
J:228452 Oshiumi H, et al., DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation. Cell Rep. 2015 May 26;11(8):1193-207 |
All: |
1 reference(s) |
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