Nprl2^tm1.2Bpt
Targeted Allele Detail

Summary

• Symbol: Nprl2^tm1.2Bpt
• Name: NPR2 like, GATOR1 complex subunit; targeted mutation 1.2, Benjamine P Tu
• MGI ID: MGI:5792912
• Gene: Nprl2 Location: Chr9:107419425-107422905 bp, + strand Genetic Position: Chr9, 58.12 cM, cytoband F1
• Alliance: Nprl2^tm1.2Bpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224837
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 1 through 9. (J:224837)

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nprl2 Mutation: 23 strains or lines available

References

• Original: J:224837 Dutchak PA, et al., Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015 Jul 21;12(3):371-9
• All: 1 reference(s)