Wdfy3^disc
Chemically induced Allele Detail

Summary

• Symbol: Wdfy3^disc
• Name: WD repeat and FYVE domain containing 3; disconnected
• MGI ID: MGI:5795594
• Gene: Wdfy3 Location: Chr5:101980822-102217787 bp, - strand Genetic Position: Chr5, 48.95 cM
• Alliance: Wdfy3^disc page

Forebrain overgrowth in Wdfy3^disc/Wdfy3^disc mutants

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Chemically induced (ENU) (Hypomorph) Mutation: Single point mutation Mutation details: This mutation was identified in a forward genetics screen for mutations affecting forebrain development in mice. A single nonsense mutation in exon 59 of 67 of the Wdfy3 gene (T to A at position 9,683 of NM_172882, aa 3,046 of 3,508) was identified as the causative mutation, and introduces a premature stop codon. (J:225200)

Identification of the Wdfy3^disc mutation

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdfy3 Mutation: 210 strains or lines available

References

• Original: J:225200 Orosco LA, et al., Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. Nat Commun. 2014;5:4692
• All: 1 reference(s)