Phlpp2tm1d(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Phlpp2tm1d(EUCOMM)Hmgu |
Name: |
PH domain and leucine rich repeat protein phosphatase 2; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:5795604 |
Gene: |
Phlpp2 Location: Chr8:110595174-110671303 bp, + strand Genetic Position: Chr8, 57.33 cM
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Alliance: |
Phlpp2tm1d(EUCOMM)Hmgu page
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IMPC: |
Phlpp2 gene page |
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Mutant Cell Line: |
HEPD0619_1_C08 |
Germline Transmission: |
Earliest citation of germline transmission:
J:231241
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 110630450 of Chromosome 8 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4 at position 110631337. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression resulted in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:231241)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Phlpp2 Mutation: |
62 strains or lines available
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Original: |
J:231241 Wen YA, et al., Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2013-23 |
All: |
2 reference(s) |
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