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Traf3ip3tm1b(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Traf3ip3tm1b(KOMP)Wtsi
Name: TRAF3 interacting protein 3; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:5795737
Gene: Traf3ip3  Location: Chr1:192857812-192883854 bp, - strand  Genetic Position: Chr1, 97.62 cM
Alliance: Traf3ip3tm1b(KOMP)Wtsi page
IMPC: Traf3ip3 gene page
Mutation
origin
Mutant Cell Line:  EPD0093_2_B04
Germline Transmission:  Earliest citation of germline transmission: J:226431
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 192879748 of Chromosome 1 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 192880831. The critical exon 3 is thus flanked by loxP sites. Cre expression without flp expression created a reporter knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. Western blot analysis confirmed the absence of protein expression in thymocytes. (J:226431)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf3ip3 Mutation:  33 strains or lines available
References
Original:  J:226431 Zou Q, et al., T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi. J Exp Med. 2015 Jul 27;212(8):1323-36
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory