About   Help   FAQ
Traf3ip3tm1c(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Traf3ip3tm1c(KOMP)Wtsi
Name: TRAF3 interacting protein 3; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5795738
Synonyms: Traf3ip3-flox
Gene: Traf3ip3  Location: Chr1:192857812-192883854 bp, - strand  Genetic Position: Chr1, 97.62 cM
Alliance: Traf3ip3tm1c(KOMP)Wtsi page
IMPC: Traf3ip3 gene page
Mutation
origin
Mutant Cell Line:  EPD0093_2_B04
Germline Transmission:  Earliest citation of germline transmission: J:226431
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 192879748 of Chromosome 1 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 192880831. The critical exon 3 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:226431)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf3ip3 Mutation:  33 strains or lines available
References
Original:  J:226431 Zou Q, et al., T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi. J Exp Med. 2015 Jul 27;212(8):1323-36
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory