Tg(Bglap2-TAg)1Rkho
Transgene Detail

Summary

• Symbol: Tg(Bglap2-TAg)1Rkho
• Name: transgene insertion 1, Rama Khokha
• MGI ID: MGI:5796023
• Synonyms: MOTO-1
• Transgene: Tg(Bglap2-TAg)1Rkho Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Tg(Bglap2-TAg)1Rkho page

Poorly calcified femur tumor with bone destruction in a Tg(Bglap2-TAg)1Rkho/0 mouse

Show the 5 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

Transgene Type: Transgenic (Inserted expressed sequence) Mutation: Insertion Mutation details: The SV40 T/t antigen (TAg) is under the control of the 1.3-kb murine osteocalcin promoter which is specific for mature osteoblasts. Three lines (1,2, and 3) were established. Transgene insertion was mapped to chromosome 12qA-B1 for this line using FISH. (J:165282)

Schematic of the Tg(Bglap2-TAg)1Rkho transgene

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Tg(Bglap2-TAg)1Rkho/0 Tg(Col1a1-cre)1Kry/0 Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.1Pngr	involves: 129P2/OlaHsd * C57BL/6 * FVB/N
cn2	Prkar1a^tm1.2Lsk/Prkar1a^+ Tg(Bglap2-TAg)1Rkho/0 Tg(Col1a1-cre)1Kry/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N
cx3	Tg(Bglap2-TAg)1Rkho/0 Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr	involves: 129P2/OlaHsd * FVB/N
cx4	Tg(Bglap2-TAg)1Rkho/0 Tnfsf11^tm1Pngr/Tnfsf11^+	involves: 129P2/OlaHsd * FVB/N
tg5  Disease Model	Tg(Bglap2-TAg)1Rkho/0	FVB/N-Tg(Bglap2-TAg)1Rkho
tg6  Disease Model	Tg(Bglap2-TAg)1Rkho/0	involves: FVB/N

Phenotypes:

Affected Systems	cn1	cn2	cx3	cx4	tg5	tg6
show or hide all annotated terms
behavior/neurological		√
abnormal motor capabilities/coordination/movement		√
paralysis		√
limbs/digits/tail			√
abnormal femur morphology			√
mortality/aging		√			√	√
premature death		√				√
decreased tumor-free survival time					√
neoplasm	√	√	√	√	√	√
increased metastatic potential					√
decreased osteosarcoma incidence			√
increased skeletal tumor incidence					√
increased osteosarcoma incidence	√	√		√	√	√
skeleton	√	√	√	√	√	√
abnormal femur morphology			√
decreased osteosarcoma incidence			√
increased skeletal tumor incidence					√
increased osteosarcoma incidence	√	√		√	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg5	tg6
osteosarcoma IDs osteosarcoma       DOID:3347 DOID:183 MESH:D012516 MESH:D018213 NCI:C9145 OMIM:259500 ORDO:668 UMLS_CUI:C0029463 UMLS_CUI:C0206639 Close	√	√

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:165282 Molyneux SD, et al., Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. J Clin Invest. 2010 Sep 1;120(9):3310-25
• All: 2 reference(s)