Tg(Bglap2-TAg)1Rkho
Transgene Detail

Summary

• Symbol: Tg(Bglap2-TAg)1Rkho
• Name: transgene insertion 1, Rama Khokha
• MGI ID: MGI:5796023
• Synonyms: MOTO-1
• Transgene: Tg(Bglap2-TAg)1Rkho Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Tg(Bglap2-TAg)1Rkho page

Poorly calcified femur tumor with bone destruction in a Tg(Bglap2-TAg)1Rkho/0 mouse

Show the 5 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

Transgene Type: Transgenic (Inserted expressed sequence) Mutation: Insertion Mutation details: The SV40 T/t antigen (TAg) is under the control of the 1.3-kb murine osteocalcin promoter which is specific for mature osteoblasts. Three lines (1,2, and 3) were established. Transgene insertion was mapped to chromosome 12qA-B1 for this line using FISH. (J:165282)

Schematic of the Tg(Bglap2-TAg)1Rkho transgene

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:165282 Molyneux SD, et al., Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. J Clin Invest. 2010 Sep 1;120(9):3310-25
• All: 2 reference(s)