Kdm1a^tm2.1Rsd
Targeted Allele Detail

Summary

• Symbol: Kdm1a^tm2.1Rsd
• Name: lysine (K)-specific demethylase 1A; targeted mutation 2.1, Michael G Rosenfeld
• MGI ID: MGI:5796137
• Gene: Kdm1a Location: Chr4:136277851-136330034 bp, - strand Genetic Position: Chr4, 68.8 cM
• Alliance: Kdm1a^tm2.1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225803
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exon 8a was floxed. Flp-mediated recombination removed the neomycin resistance cassette. (J:225803)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdm1a Mutation: 40 strains or lines available

References

• Original: J:225803 Wang J, et al., LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control. Nat Neurosci. 2015 Sep;18(9):1256-64
• All: 1 reference(s)