Tg(Prnp-PFN1)34Zxu
Transgene Detail

Summary

• Symbol: Tg(Prnp-PFN1)34Zxu
• Name: transgene insertion 34, Zuoshang Xu
• MGI ID: MGI:5796265
• Synonyms: Prp-PFN1^WT
• Transgene: Tg(Prnp-PFN1)34Zxu Location: unknown
• Alliance: Tg(Prnp-PFN1)34Zxu page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-PFN1)34Zxu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PFN1 (5216)

  Pfn1	(MGI:97549)

• Mutation details: The transgenic construct contains a human profilin 1 cDNA sequence with a V5 tag (45 bp) fused to the N-terminus and inserted between exon 2 and exon 3 of mouse prion protein gene at a unique XhoI site in the MoPrP.Xho plasmid vector. Founder line 34 was found to have stable high expression predominantly in the central nervous system. (J:235427)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:235427 Yang C, et al., Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6209-E6218
• All: 2 reference(s)