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Commd9tm1c(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Commd9tm1c(KOMP)Wtsi
Name: COMM domain containing 9; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5796331
Synonyms: Commd9F
Gene: Commd9  Location: Chr2:101716607-101731984 bp, + strand  Genetic Position: Chr2, 54.07 cM
Alliance: Commd9tm1c(KOMP)Wtsi page
IMPC: Commd9 gene page
Mutation
origin
Mutant Cell Line:  EPD0136_6_D10
Germline Transmission:  Earliest citation of germline transmission: J:230747
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 101726764 of Chromosome 2 upstream of exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 3 at position 101727794. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, resulting in the deletion of the lacZ sequences and the neomycin selection cassette. Exon 3 is thus flanked by loxP sites. (J:230747)
Generation of the Commd9tm1c(KOMP)Wtsi allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Commd9 Mutation:  50 strains or lines available
References
Original:  J:230747 Li H, et al., Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. J Cell Biol. 2015 Nov 9;211(3):605-17
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory