Pten^tm1.1Jaes
Targeted Allele Detail

Summary

• Symbol: Pten^tm1.1Jaes
• Name: phosphatase and tensin homolog; targeted mutation 1.1, Jose A Esteban
• MGI ID: MGI:5796481
• Synonyms: Pten^deltaPDZ, Pten^{tm(Q399stop)amc}
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1.1Jaes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234430
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The PDZ-binding domain was deleted by substituting glutamine codon 399 (CAA) with a stop codon (TAA) in exon 8. Cre-mediated recombination removed the loxp-flanked neomycin cassette downstream of exon 8. (J:234430)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:234430 Knafo S, et al., PTEN recruitment controls synaptic and cognitive function in Alzheimer's models. Nat Neurosci. 2016 Mar;19(3):443-53
• All: 4 reference(s)