Top6bl^em1Arte
Endonuclease-mediated Allele Detail

Summary

• Symbol: Top6bl^em1Arte
• Name: TOP6B like initiator of meiotic double strand breaks; endonuclease-mediated mutation 1, TaconicArtemis
• MGI ID: MGI:5796829
• Synonyms: Top6bl^-i
• Gene: Top6bl Location: Chr19:4675762-4748696 bp, - strand Genetic Position: Chr19, 4.08 cM
• Alliance: Top6bl^em1Arte page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• CRISPR/Cas technology targeting exon 9 inserted 4 bp to induce a frameshift. (J:229524)

Expression

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Top6bl Mutation: 22 strains or lines available

References

• Original: J:229524 Robert T, et al., The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. 2016 Feb 26;351(6276):943-9
• All: 1 reference(s)