Kdm6b^tm1.1Rbo
Targeted Allele Detail

Summary

• Symbol: Kdm6b^tm1.1Rbo
• Name: KDM1 lysine (K)-specific demethylase 6B; targeted mutation 1.1, Remy Bosselut
• MGI ID: MGI:5796917
• Synonyms: Jmjd3^f
• Gene: Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
• Alliance: Kdm6b^tm1.1Rbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227020
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains an FRT-loxP-neomycin-FRT-loxP cassette introduced into intron 13 and a loxP site placed into intron 20. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 14 through 20 floxed. (J:227020)

Expression

In Mice Carrying this Mutation:	31 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdm6b Mutation: 67 strains or lines available

References

• Original: J:227020 Manna S, et al., Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation. Nat Commun. 2015;6:8152
• All: 11 reference(s)