Sh3pxd2b^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Sh3pxd2b^tm1.1Arte
• Name: SH3 and PX domains 2B; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5800300
• Gene: Sh3pxd2b Location: Chr11:32297820-32378173 bp, + strand Genetic Position: Chr11, 18.89 cM
• Alliance: Sh3pxd2b^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235640
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flaneked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 5. A second loxP site was inserted downstream, of exon 6. Cre-mediated mutation removed the selection cassette and exons 5 and 6. Western blot analysis confirmed the absence of protein expression in skeletal muscle, brain, heart, lung, spleen and white adipose tissue. (J:235640)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh3pxd2b Mutation: 38 strains or lines available

References

• Original: J:235640 Dulk M, et al., The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages. Sci Rep. 2016 Oct 06;6:34280
• All: 3 reference(s)