Sik3^Slp
Chemically induced Allele Detail

Summary

• Symbol: Sik3^Slp
• Name: SIK family kinase 3; sleepy
• MGI ID: MGI:5800458
• Gene: Sik3 Location: Chr9:45924118-46135492 bp, + strand Genetic Position: Chr9, 25.36 cM
• Alliance: Sik3^Slp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A point mutation in intron 13. This mutation affects the splice donor site and results in skipping of exon 13. Western blot analysis confirmed the expression of a smaller than full-length protein product. (J:236598)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sik3 Mutation: 72 strains or lines available

References

• Original: J:236598 Funato H, et al., Forward-genetics analysis of sleep in randomly mutagenized mice. Nature. 2016 Nov 17;539(7629):378-383
• All: 4 reference(s)