Fpr3^del
Spontaneous Allele Detail

Summary

• Symbol: Fpr3^del
• Name: formyl peptide receptor 3; deletion
• MGI ID: MGI:5800460
• Synonyms: Fpr3delta424-435
• Gene: Fpr3 Location: Chr17:18190720-18191939 bp, + strand Genetic Position: Chr17, 10.66 cM
• Alliance: Fpr3^del page

Mutation origin

• Strain of Origin: various

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Nineteen strains (129X1/Sv, 129P2/OlaHsd, 129S1/SvImJ, 129S5SvEvBrd, AKR/J, A/J, BALB/cJ, C3H/HeH, C3H/HeJ, CBA/J, DBA/1J, DBA/2J, LP/J, NZO/HILtJ, RF/J, SEA/GnJ, FVB/NCrl, FVB/NJ, BUB/BnJ, ZALENDE/EiJ, LEWES/EiJ and WSB/EiJ) contain an in-frame 12 bp deletion within the gene spanning the basepairs 424 to 435. Immunocytochemistry analysis confirmed the absence of protein expression in vomeronasal sensory epithelium and neutrophil granulocytes. Furthermore, HEK293T cells expressing Fpr3^del showed missing receptor protein expression and loss of function. This deletion is not detected in 13 other strains (C57Bl/6NCrl, C57Bl/6NJ, C57Bl/10J, C57BR/cdJ, C57L/J, C58/J, I/LnJ, NZB/B1NJ, NZB/Ola, NZW/LacJ, KK/HiJa, NOD/ShiLtJ, ST/bJ, SPRET/EiJ, CZE/DT, PWK/PhJ, GER/DT, FRA/DT, CAST/EiJ and KAZ/DT). (J:233707)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fpr3 Mutation: 30 strains or lines available

References

• Original: J:233707 Stempel H, et al., Strain-specific Loss of Formyl Peptide Receptor 3 in the Murine Vomeronasal and Immune Systems. J Biol Chem. 2016 Apr 29;291(18):9762-75
• All: 2 reference(s)