Tg(Myh6*/tetO-SCN5A*F1759A)#Marx
Transgene Detail
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Symbol: |
Tg(Myh6*/tetO-SCN5A*F1759A)#Marx |
Name: |
transgene insertion, Steven O Marx |
MGI ID: |
MGI:5800483 |
Synonyms: |
F1759A-Nav1.5 |
Transgene: |
Tg(Myh6*/tetO-SCN5A*F1759A)#Marx Location: unknown
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Alliance: |
Tg(Myh6*/tetO-SCN5A*F1759A)#Marx page
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Atrial and ventricular cardiomyopathy in Tg(Myh6*/tetO-SCN5A*F1759A)#Marx/0 Tg(Myh6-rtTA)8585Jam/0 mice
Show the 1 phenotype image(s) involving this allele.
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Tg(Myh6*/tetO-SCN5A*F1759A)#Marx expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
SCN5A (6331) |
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Mutation details: A FLAG-tagged human SCN5A cDNA with the F1759A mutation in the local anesthetic binding site is under the control of a tetracycline-inducible modified murine alpha-MHC promoter. This mutation results in lidocaine-resistance and causes window current and persistent sodium current. Four lines were established however, the pound symbol (#) is used when line is not specified and/or lines are pooled.
(J:229825)
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Schematic of the Tg(Myh6*/tetO-SCN5A*F1759A)#Marx construct |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:229825 Wan E, et al., Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. J Clin Invest. 2016 Jan;126(1):112-22 |
All: |
2 reference(s) |
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