About   Help   FAQ
Tg(Myh6*/tetO-SCN5A*F1759A)#Marx
Transgene Detail
Summary
Symbol: Tg(Myh6*/tetO-SCN5A*F1759A)#Marx
Name: transgene insertion, Steven O Marx
MGI ID: MGI:5800483
Synonyms: F1759A-Nav1.5
Transgene: Tg(Myh6*/tetO-SCN5A*F1759A)#Marx  Location: unknown  
Alliance: Tg(Myh6*/tetO-SCN5A*F1759A)#Marx page
Atrial and ventricular cardiomyopathy in Tg(Myh6*/tetO-SCN5A*F1759A)#Marx/0 Tg(Myh6-rtTA)8585Jam/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(Myh6*/tetO-SCN5A*F1759A)#Marx expresses 1 gene
 
Mutation detailsA FLAG-tagged human SCN5A cDNA with the F1759A mutation in the local anesthetic binding site is under the control of a tetracycline-inducible modified murine alpha-MHC promoter. This mutation results in lidocaine-resistance and causes window current and persistent sodium current. Four lines were established however, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:229825)
Schematic of the Tg(Myh6*/tetO-SCN5A*F1759A)#Marx construct
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:229825 Wan E, et al., Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. J Clin Invest. 2016 Jan;126(1):112-22
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory