Dnm1^tm1.2Frk
Targeted Allele Detail

Summary

• Symbol: Dnm1^tm1.2Frk
• Name: dynamin 1; targeted mutation 1.2, Wayne N Frankel
• MGI ID: MGI:5800540
• Synonyms: Dnm1^deltaa
• Gene: Dnm1 Location: Chr2:32198483-32243350 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Dnm1^tm1.2Frk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235711
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 10a was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of exon 10a. Cre-mediated recombination removed exon 10a. Western blot analysis confirmed the absence of isoform a but expression of isoform b. (J:235711)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnm1 Mutation: 40 strains or lines available

References

• Original: J:235711 Asinof S, et al., Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy. Neurobiol Dis. 2016 Nov;95:1-11
• All: 1 reference(s)