Xcr1^tm4(cre)Ksho
Targeted Allele Detail

Summary

• Symbol: Xcr1^tm4(cre)Ksho
• Name: chemokine (C motif) receptor 1; targeted mutation 4, Tsuneyasu Kaisho
• MGI ID: MGI:5803711
• Synonyms: Xcr1^cre
• Gene: Xcr1 Location: Chr9:123681380-123691094 bp, - strand Genetic Position: Chr9, 74.71 cM, cytoband F4
• Alliance: Xcr1^tm4(cre)Ksho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235786
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Xcr1^tm4(cre)Ksho expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Xcr1 (MGI:1346338)

• A cre recombinase gene and a FRT-flanked neomycin resistance cassette replaced the coding sequence. (J:235786)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Xcr1 (mouse) Summary of all recombinase alleles driven by Xcr1. Alliance mouse Xcr1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Xcr1 Mutation: 33 strains or lines available

References

• Original: J:235786 Ohta T, et al., Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci Rep. 2016 Mar 23;6:23505
• All: 4 reference(s)