Fuca1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fuca1^em1(IMPC)J
• Name: fucosidase, alpha-L- 1, tissue; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5803874
• Synonyms: Fuca1^em1J
• Gene: Fuca1 Location: Chr4:135648037-135667611 bp, + strand Genetic Position: Chr4, 68.01 cM, cytoband D3
• Alliance: Fuca1^em1(IMPC)J page
• IMPC: Fuca1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from project Fuca1-8333J-F7982 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GGACTAGATACAGATTCTGA, GTAATACCTGTCCGTAAGAC, TTCAGAACCTGTAATTCATA and TCAACTACCTTATGAATTAC, which resulted in a 186 bp deletion beginning at Chromosome 4 positive strand position 135,929,843 bp, AGACTGGACTAGATACAGAT, and ending after GTGGTTATCAACTACCTTAT at 135,930,028 bp (GRCm38/mm10). This mutation deletes exon 4 and 80 bp of flanking intronic sequence including the splice acceptor and donor, and is predicted to cause a change of amino acid sequence after residue 206 and early truncation 3 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fuca1 Mutation: 34 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)