Nfe2l1^tm1.1Mym
Targeted Allele Detail

Summary

• Symbol: Nfe2l1^tm1.1Mym
• Name: nuclear factor, erythroid derived 2,-like 1; targeted mutation 1.1, Masayuki Yamamoto
• MGI ID: MGI:5804004
• Synonyms: Nrf1^-
• Gene: Nfe2l1 Location: Chr11:96708240-96720794 bp, - strand Genetic Position: Chr11, 60.12 cM, cytoband D-E
• Alliance: Nfe2l1^tm1.1Mym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143468
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and a floxed neo cassette followed by an IRES-EGFP replaces the non-coding portion of exon 4. Cre-mediated recombination excised the floxed region. (J:143468)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfe2l1 Mutation: 42 strains or lines available

References

• Original: J:143468 Ohtsuji M, et al., Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J Biol Chem. 2008 Nov 28;283(48):33554-62
• All: 4 reference(s)