Cnot3^tm1.2Tya
Targeted Allele Detail

Summary

• Symbol: Cnot3^tm1.2Tya
• Name: CCR4-NOT transcription complex, subunit 3; targeted mutation 1.2, Tadashi Yamamoto
• MGI ID: MGI:5804097
• Synonyms: Cnot3^flox
• Gene: Cnot3 Location: Chr7:3648267-3664108 bp, + strand Genetic Position: Chr7, 2.1 cM
• Alliance: Cnot3^tm1.2Tya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227564
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A PGK-neo cassette flanked by two loxP sites was inserted in the intron preceding exon 2 and another loxP site was inserted following exon 9. Cre-mediated recombination removed the selection cassette and left exons 2 through 9 floxed. (J:227564)

Expression

In Mice Carrying this Mutation:

156229 assay results 6 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnot3 Mutation: 35 strains or lines available

References

• Original: J:227564 Inoue T, et al., CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability. J Exp Med. 2015 Aug 24;212(9):1465-79
• All: 6 reference(s)