Nfatc1^em3(dre)Bzsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nfatc1^em3(dre)Bzsh
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; endonuclease-mediated mutation 3, Bin Zhou
• MGI ID: MGI:5804102
• Synonyms: Nfatc1-Dre, Nfatc1^{tm3.1(dreo)Bz}
• Gene: Nfatc1 Location: Chr18:80649420-80756286 bp, - strand Genetic Position: Chr18, 53.66 cM, cytoband E4
• Alliance: Nfatc1^em3(dre)Bzsh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Nfatc1^em3(dre)Bzsh expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nfatc1 (MGI:102469)

• Mutation details: The line was generated by inserting the 2A peptide sequence derived from porcine teschovirus-1 followed by the cDNA encoding Dre recombinase and polyadenylation sequence into the exon 9 of Nfatc1 by homologous recombination using the CRISPR/Cas9 technology. (J:236001)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nfatc1 (mouse) Summary of all recombinase alleles driven by Nfatc1. Comparative matrix view of recombinase activities Alliance mouse Nfatc1 gene page

Expression

In Mice Carrying this Mutation:

38 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfatc1 Mutation: 49 strains or lines available

References

• Original: J:236001 Zhang H, et al., Endocardium Contributes to Cardiac Fat. Circ Res. 2016 Jan 22;118(2):254-65
• All: 5 reference(s)