Npr3^{em1(cre/ERT2)Bzsh}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Npr3^{em1(cre/ERT2)Bzsh}
• Name: natriuretic peptide receptor 3; endonuclease-mediated mutation 1, Bin Zhou
• MGI ID: MGI:5804184
• Synonyms: Npr3-creER, Npr3^{tm1.1(cre/ERT2)Bz}, Npr3^{tm1.1(cre/ERT2)Bzsh}
• Gene: Npr3 Location: Chr15:11839982-11907287 bp, - strand Genetic Position: Chr15, 5.83 cM
• Alliance: Npr3^{em1(cre/ERT2)Bzsh} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Npr3^{em1(cre/ERT2)Bzsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Npr3 (MGI:97373)

• Mutation details: Using the CRISPR/Cas9 technology, a cDNA encoding cre/ERT2 followed by the Woodchuck Post-transcriptional regulatory element and a polyadenylation sequence was inserted in frame with the translational start codon of the Npr3 gene. (J:231966)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Npr3 (mouse) Summary of all recombinase alleles driven by Npr3. Comparative matrix view of recombinase activities Alliance mouse Npr3 gene page

Expression

In Mice Carrying this Mutation:

58 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npr3 Mutation: 49 strains or lines available

References

• Original: J:231966 Zhang H, et al., Genetic lineage tracing identifies endocardial origin of liver vasculature. Nat Genet. 2016 May;48(5):537-43
• All: 8 reference(s)