Adam7^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Adam7^tm1Tigm
• Name: a disintegrin and metallopeptidase domain 7; targeted mutation 1, Texas A&M Institute for Genomic Medicine
• MGI ID: MGI:5804545
• Gene: Adam7 Location: Chr14:68734785-68771138 bp, - strand Genetic Position: Chr14, 35.69 cM
• Alliance: Adam7^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226260
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The beta-geo/puromycin resistance cassette replaced exons 1 and 2. Western blot analysis confirmed the absence of protein expression in the epididymis. (J:226260)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam7 Mutation: 48 strains or lines available

References

• Original: J:226260 Choi H, et al., Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Biol Reprod. 2015 Sep;93(3):70
• All: 1 reference(s)