Hrq8^C3HeB/FeJ
QTL Variant Detail

Summary

• QTL variant: Hrq8^C3HeB/FeJ
• Name: heart rate QTL 8; C3HeB/FeJ
• MGI ID: MGI:5804641
• QTL: Hrq8 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: C3HeB/FeJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:190489

In a previous study, the authors reported that heart rate (HR) was approximately 80 beats/min higher in SJL/J compared with C3HeB/FeJ mice, with no difference in systolic blood pressure (SBP). In the current study, linkage analysis was performed on a mapping population of 134 (C3HeB/FeJ x SJL/J) backcross mice to identify QTL related to HR and SBP as measured by tail-cuff plethysmography. The authors used 80 microsatellite markers to perform genetic linkage mapping analysis. They identified one QTL reaching genome-wide significance:

QTL Hrq8 (Heart rate QTL 8) maps to Chromosome 7 with a peak LOD score of 6.7 at 41 cM. HR was greater in N2 progeny homozygous for the SJL/J allele compared with the C3HeB/FeJ allele at the markers D7Mit69.1 and D7Mit350.1.

The authors also performed a GWAS mapping study using 322 mice from the Hybrid Mouse Diversity Panel (HMDP; 58 strains, n = 56/strain). The HMDP contains 4 million informative SNP markers and helped the authors to identify one genomic locus reaching genome-wide significance:

QTL Hrq9 (Heart rate QTL 9) maps to Chromosome 7 with a peak located at 64.9 Mb (64.2 - 65.1). The peak association was observed for 17 SNPs that are localized within three GABA(A) receptor genes - Gabrb3, Gabra5, and Gabrg3 - encoding receptor subunits for the inhibitory neurotransmitter GABA(A). Although it co-localizes with the Hrq8 locus, no alleles were described for Hrq9.

References

• Original: J:190489 Smolock EM, et al., Genetic locus on mouse chromosome 7 controls elevated heart rate. Physiol Genomics. 2012 Jul 3;44(13):689-98
• All: 1 reference(s)