Sln^{tm1.1(cre)Krc}
Targeted Allele Detail

Summary

• Symbol: Sln^{tm1.1(cre)Krc}
• Name: sarcolipin; targeted mutation 1.1, Kenneth R Chien
• MGI ID: MGI:5804671
• Synonyms: SLN-Cre
• Gene: Sln Location: Chr9:53757535-53761133 bp, + strand Genetic Position: Chr9, 29.24 cM, cytoband C
• Alliance: Sln^{tm1.1(cre)Krc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233948
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Sln^{tm1.1(cre)Krc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sln (MGI:1913652)

• Mutation details: Exon 2 of the Sln locus including the 1st ATG was replaced with Cre recombinase and FRT flanked neomycin resistant cassette by homologous recomibination. The neo cassette was removed in the final line. The knocked in cre gene is expressed by the Sln promoter in atrial liniage cells starting at day E10.0. (J:233948)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sln (mouse) Summary of all recombinase alleles driven by Sln. Alliance mouse Sln gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sln Mutation: 11 strains or lines available

References

• Original: J:233948 Nakano H, et al., Cardiac origin of smooth muscle cells in the inflow tract. J Mol Cell Cardiol. 2011 Feb;50(2):337-45
• All: 6 reference(s)