Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Zijie Sun
• MGI ID: MGI:5804675
• Synonyms: R26hAR^loxP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234601
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AR (367)

  Ar	(MGI:88064)

• Mutation details: The targeting construct inserted into the locus a CAG promoter, floxed stop cassette, a flag-tagged human sequence and polyadenylation sequence. (J:234601)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:234601 Zhu C, et al., Conditional expression of the androgen receptor induces oncogenic transformation of the mouse prostate. J Biol Chem. 2011 Sep 23;286(38):33478-88
• All: 4 reference(s)