Tg(Vim-cre/ERT2)#Rshw
Transgene Detail

Summary

• Symbol: Tg(Vim-cre/ERT2)#Rshw
• Name: transgene insertion, Robert F Schwabe
• MGI ID: MGI:5804689
• Synonyms: Vim-CreER
• Transgene: Tg(Vim-cre/ERT2)#Rshw Location: unknown
• Alliance: Tg(Vim-cre/ERT2)#Rshw page

Transgene origin

• Strain of Origin: (CBA x C57BL/6J)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Vim-cre/ERT2)#Rshw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Vim

• Mutation details: A cre/ERT2 cassette was inserted at the ATG codon in exon 1 of the Vim gene in the BAC by recombineering methods. The neo cassette was removed by flippase, and the modified BAC construct was injected into fertilized CBA x C57BL/6J oocytes. One of three founders was crossed to reporter mice for analyses. One line shows strong cre-recombinase expression induction after tamoxifen injection, however specific line number(s) used for the experiments are not given. (J:231716)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Vim (species not specified) Summary of all recombinase alleles driven by Vim.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:231716 Troeger JS, et al., Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. Gastroenterology. 2012 Oct;143(4):1073-83.e22
• All: 5 reference(s)