Il2^{tm1.1(cre)Iwsh}
Targeted Allele Detail

Summary

• Symbol: Il2^{tm1.1(cre)Iwsh}
• Name: interleukin 2; targeted mutation 1.1, Makio Iwashima
• MGI ID: MGI:5804692
• Synonyms: il-2^cre
• Gene: Il2 Location: Chr3:37174862-37180103 bp, - strand Genetic Position: Chr3, 18.3 cM, cytoband B-C
• Alliance: Il2^{tm1.1(cre)Iwsh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231266
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Il2^{tm1.1(cre)Iwsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Il2 (MGI:96548)

• Mutation details: A targeting vector was designed to insert a cre recombinase cDNA, an frt-flanked neo cassette, and an internal ribosome entry site (IRES) into the Il2 gene just upstream of the first codon. The mice with correct targeted inserts were bred with Actin-FLPe females (on a C57BL/6 congenic background) to remove the neo selection cassette. (J:231266)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Il2 (mouse) Summary of all recombinase alleles driven by Il2. Alliance mouse Il2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il2 Mutation: 43 strains or lines available

References

• Original: J:231266 Yamamoto M, et al., Ontogeny and localization of the cells produce IL-2 in healthy animals. Cytokine. 2013 Mar;61(3):831-41
• All: 2 reference(s)