Sdhc^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Sdhc^{tm1c(EUCOMM)Wtsi}
• Name: succinate dehydrogenase complex, subunit C, integral membrane protein; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5805498
• Synonyms: Sdhc^fl
• Gene: Sdhc Location: Chr1:170956726-170978209 bp, - strand Genetic Position: Chr1, 78.99 cM
• Alliance: Sdhc^{tm1c(EUCOMM)Wtsi} page
• IMPC: Sdhc gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233463
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 170965856 of Chromosome 1 upstream of exon 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the exon 4 at position 170966998. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, leaving exon 4 flanked by loxP sites. (J:233463, J:284745)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sdhc Mutation: 83 strains or lines available

References

• Original: J:233463 Her YF, et al., Oxygen concentration controls epigenetic effects in models of familial paraganglioma. PLoS One. 2015;10(5):e0127471
• All: 5 reference(s)