Prkd2^tm1.1Shoy
Targeted Allele Detail

Summary

• Symbol: Prkd2^tm1.1Shoy
• Name: protein kinase D2; targeted mutation 1.1, Sho Yamasaki
• MGI ID: MGI:5805706
• Synonyms: PKD2^fl
• Gene: Prkd2 Location: Chr7:16576827-16604386 bp, + strand Genetic Position: Chr7, 9.15 cM
• Alliance: Prkd2^tm1.1Shoy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236298
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 or C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 15. A floxed neomycin resistance cassette was inserted downstream of exon 16. Cre-mediated recombination removed the selection cassette and left exons 15 and 6 floxed. (J:236298)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkd2 Mutation: 41 strains or lines available

References

• Original: J:236298 Ishikawa E, et al., Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat Commun. 2016 Sep 27;7:12756
• All: 2 reference(s)