Prkd3^tm1.1Shoy
Targeted Allele Detail

Summary

• Symbol: Prkd3^tm1.1Shoy
• Name: protein kinase D3; targeted mutation 1.1, Sho Yamasaki
• MGI ID: MGI:5805707
• Synonyms: PKD3^fl
• Gene: Prkd3 Location: Chr17:79256834-79328245 bp, - strand Genetic Position: Chr17, 49.69 cM, cytoband E3
• Alliance: Prkd3^tm1.1Shoy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236298
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 or C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 13. A floxed neomycin resistance cassette was inserted downstream of exon 15. Cre-mediated recombination removed the selection cassette and left exons 13 through 15 floxed. (J:236298)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkd3 Mutation: 62 strains or lines available

References

• Original: J:236298 Ishikawa E, et al., Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat Commun. 2016 Sep 27;7:12756
• All: 4 reference(s)