Ptpn6^em1.1Shoy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptpn6^em1.1Shoy
• Name: protein tyrosine phosphatase, non-receptor type 6; endonuclease-mediated mutation 1.1, Sho Yamasaki
• MGI ID: MGI:5805709
• Synonyms: SHP-1^S557A
• Gene: Ptpn6 Location: Chr6:124697670-124715672 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Ptpn6^em1.1Shoy page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neomycin resistance cassette inserted upstream of exon 12. Exon 14 was replaced with one in which nucleotide substitution(s) result(s) in the amino acid substitution of alanine for serine at position 557 (S557A). Cre-mediated recombination removed the selection cassette. (J:236298)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn6 Mutation: 49 strains or lines available

References

• Original: J:236298 Ishikawa E, et al., Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat Commun. 2016 Sep 27;7:12756
• All: 1 reference(s)