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Mir196btm1.1Wtsi
Targeted Allele Detail
Summary
Symbol: Mir196btm1.1Wtsi
Name: microRNA 196b; targeted mutation 1.1, Wellcome Trust Sanger Institute
MGI ID: MGI:5805882
Synonyms: Mir196btm1.1(mirKO)Wtsi
Gene: Mir196b  Location: Chr6:52207061-52207145 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance: Mir196btm1.1Wtsi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226712
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of the PGK_EM7_PuDtk_bGHpA cassette created a deletion of size 436 starting at position 52159915 and ending at position 52159479 of Chromosome 6 (Genome Build 37). This deletion eliminates the DNA sequence for this microRNA. The cassette is composed of a loxP site followed by an F3 site followed by a PGK-puromycin-delta-tk cassette, a loxP site and finally an FRT site. Cre-mediated recombination removed the selection cassette. (J:226712)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir196b Mutation:  2 strains or lines available
References
Original:  J:226712 Wong SF, et al., Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4884-93
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory