Tg(Rho-Arl3*Q71L)#Visu
Transgene Detail

Summary

• Symbol: Tg(Rho-Arl3*Q71L)#Visu
• Name: transgene insertion, Visvanathan Ramamurthy
• MGI ID: MGI:5806092
• Transgene: Tg(Rho-Arl3*Q71L)#Visu Location: unknown
• Alliance: Tg(Rho-Arl3*Q71L)#Visu page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Rho-Arl3*Q71L)#Visu expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Arl3 (MGI:1929699)

• Mutation details: The full-length murine Arl3 with the Q71L dominant active mutation is under the control of a 4.4-kb rhodopsin promoter. A tandem C-terminally hemagglutinin (HA) and FLAG fusion tags were added. The rhodopsin promoter drives the expression of the gene as early as postnatal day 4 in rod photoreceptor cells of the retina. Immunoblotting indicates 2.5-fold overexpression of the mutant over endogenous levels. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:235882)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:235882 Wright ZC, et al., ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment. Hum Mol Genet. 2016 May 15;25(10):2031-2044
• All: 1 reference(s)